Ethan Goldberg, MD, PhD

The University of Pennsylvania School of Medicine

Ethan M. Goldberg, M.D., Ph.D, is Associate Professor in the Division of Neurology at The Children’s Hospital of Philadelphia (CHOP) and Departments of Neurology & Neuroscience at The University of Pennsylvania Perelman School of Medicine. He received his undergraduate degree in Neurobiology from Harvard University; M.D. and Ph.D. from NYU studying ion channels and cellular and synaptic neurophysiology as well as interneuron diversity in the laboratory of Bernardo Rudy; and then undertook general pediatric medicine, pediatric neurology, adult neurology, and experimental epilepsy training at CHOP and The University of Pennsylvania. He is a practicing pediatric neurologist and Director of the Epilepsy NeuroGenetics Initiative (ENGIN) at CHOP where he specializes in the diagnosis and care of children with complex neurological disorders including epilepsy, developmental delay/intellectual disability, and autism spectrum disorder. His biomedical research lab studies basic mechanisms of seizures and epilepsy and neurodevelopmental disorders, with a particular interest in ion channelopathies and how genetic variation in ion channel genes leads to human disease. His lab uses a range of approaches including: human and mouse genetics; ion channel, cellular and synaptic neurophysiology; pharmacology; induced pluripotent stem cell technology and cell-based therapy; behavior; imaging approaches including two-photon microscopy in experimental systems; and computational modeling. He is recipient of the Grass Foundation – ANA Award in Neuroscience in 2019 and the Fritz E. Dreifuss Award from the American Epilepsy Society in 2021. His work is supported by the Dana Foundation, March of Dimes, Dravet Syndrome Foundation, the Burroughs Wellcome Fund, and NIH NINDS.


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