Peripheral Contributions to Neurologic Disorders: Adaptive Immunity and Metabolic Influences

Date/Time: Tuesday, October 25, 2022 - 8:45 AM – 10:45 AM
Track: Plenary Session
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In this session, panelists will discuss the recent discovery of peripheral contributions to the pathomechanisms of neurological disorders, including Alzheimer’s disease and Parkinson’s disease. While these neurological disorders have the primary pathology in the central nervous system, the metabolic controls and immune-mediated mechanism from the body have recently been found to be critically important in modulating the neurodegenerative processes. These novel pathways are now at the forefront of therapeutic development. Specifically, insulin and metabolic controls are known to influence how the protein accumulations and aggregations in the brain, which could be the common pathways across neurodegenerative disorders. Immunological cells, such as T cells coming from the peripheral system, can accelerate the neurodegeneration in the parkinsonism disorders and the antigen-specific mechanism may explain selective vulnerability in these diseases, To review the field, Panelists will gather evidence from animal models as well as patients to provide context for attendees and the overview for recent advances. This session will further create dialogues between neurologists and neuroscientists to develop ways to treat these neurodegenerative diseases.

Chair: Sheng-Han Kuo, MD

Co-Chair: Matthew Robert Burns, MD, PhD


  • Understand the role of insulin in metabolic control of neurodegenerative disease
  • Appreciate the interaction between T cells and synuclein in Parkinson’s disease
  • Recognize the regulatory influence of meningeal lymphatics on microglia
  • Identify mechanisms of peripheral immune cells in multiple system atrophy

Metabolic Controls and Insulin Across Neurogenerative Diseases


Synuclein Recognizing T Cells Contribute to Parkinson’s Disease


Meningeal Lymphatics Regulate Microglia in Alzheimer’s Disease


Infiltration of Peripheral Immune Cells in Multiple System Atrophy


A Novel Mouse Model of Cerebral Demyelination in X-Linked Adrenoleukodystrophy Highlights NLRP3 Activation in Lesion Pathogenesis    

Emerging Scholar Speaker: Isha Srivastava, MD, PhD, Stanford University 

Proinflammatory Cytokines within the Cerebrospinal Fluid of Patients with Intraventricular Hemorrhage Are Associated with Outcomes

Emerging Scholar Speaker: Jessica Magid-Bernstein, MD, PhD, Yale School of Medicine