Opening Symposium: Brain Organoid Models of Neurological Disorders

Plenary Session

Date/Time: Saturday, October 22, 2022 - 5:45 PM – 7:15 PM
Track: Opening Symposium
Room: Grand C-F
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Description:

Human brain organoids are an exciting new approach to study brain disorders using 3D human cerebral structures. Brain organoid methods involve growing human pluripotent stem cell (hPSC) aggregates in suspension, with or without patterning factors, that then differentiate into self-organizing cerebral-like 3D neural structures. Depending upon the specific protocol, the structures resemble diverse regions of brain and recapitulate several key in vivo features of brain organogenesis. Because of limited acess to human brain tissue and critical differences between human and mouse brain, brain organoids are attractive models for studies of unique aspects of brain development and function, and allow modeling of human brain disorders in 3D human tissue. A growing number of protocols have been developed to differentiate organoids that partly recapitulate specific CNS regions such as the cortex, hippocampus, thalamus, choroid plexus and others. Other protocols may be used to enrich for specific cell types, including oligodendrocytes. In addition, the recent development of assembloid protocols enables modeling of multiple brain regions and their connections, and advances are ongoing to combine brain organoids with other cell types (e.g., microglia, vascular cells). The techniques are being applied for mechanistic studies and pharmacological assays for various neurological disorders. This symposium will highlight recent work using brain organoid models to explore neurodegenerative disease, genetic epilepsies, CNS infections, brain evolutionary mechanisms and neurodevelopmental disorders.

Chair: Jack M. Parent, MD, FANA

Co-Chair: Sally Temple, PhD

Objectives:

  • Learners need to describe the describe the use of brain organoids to study development, function and diseases of the brain.
  • Learners need to discuss the advantages and limitations of brain organoid models.
  • Learners need to explain recent advances and future directions in the brain organoid field.

Brain Organoids to Study Evolution and Disease

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Human Neurodevelopmental Disorders Modeled in 2-D and Brain Organoid Cultures

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Fusion Brain Organoid Studies to Uncover Circuit Dysfunction in Genetic Epilepsy

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Human Brain Organoid Models of Neurodegenerative Diseases 

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