Novel Perspectives on Neurodegeneration

Date/Time: Sunday, October 23, 2022 - 9:15 AM – 11:30 AM
Track: Plenary Session
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Discussions of neurodegenerative disorders typically focus on one or other specific disease such as Alzheimer’s disease. This symposium instead examines cross-cutting mechanisms and approaches, the importance of which is increasingly being appreciated. Dr. Julie Schneider will open the symposium with an account of the very frequent co-existence of multiple neuropathologies at autopsy, in large samples, implying that a focus on a single causal cascade may be too limited. Dr. David Holtzman will next present a therapeutic approach targeting apolipoprotein E4, showing how this can ameliorate levels of both amyloid and tau, as opposed to the currently prevalent preoccupation with monoclonal antibodies to clear accumulated amyloid. Dr. Ana Maria Cuervo will then discuss chaperone-mediated autophagy and its role in aging and neurodegeneratiom. Finally, Dr. Vassilis Koliatsos will talk about mechanisms of axonal degeneration in the CNS, with a focus on traumatic brain injury.

Chair: Krishnankutty Sathian, MBBS, PhD, FANA

Co-Chair: Stefanie Geisler, MD


  • Appreciate the frequent coexistence of multiple neuropathologies in aging-associated neurodegeneration, and incorporate into clinical diagnosis and management
  • Appreciate the multiple genetic factors and pathophysiologic processes underlying neurodegeneration and stimulate thinking about common mechanisms across multiple disorders
  • Enhance understanding of therapeutic approaches to neurodegeneration and modify counseling and treatment accordingly 

Multiple Neuropathologies in Aging 


The Genetics of Neurodegenerative Diseases: from Rare Populations to Common Variants


APOE4 As a Therapeutic Target in Neurodegeneration 


Mechanisms of Axonopaty in the CNS 


Multiple Coexisting Pathologies Were Associated with Rapid Cognitive Decline in Dementia with Lewy Bodies: An Autopsy Study of 62 Prospectively Followed Patients

Emerging Scholar Speaker: Shunsuke Koga, MD, PhD, Mayo Clinic

Tissue MR Signal Heterogeneity Follows Disease Severity and Reflects Underlying Ischemia in Cerebral Small Vessel Disease

Emerging Scholar Speaker: Peter Kang, MD, MSCI, Washington University in St. Louis