Epilepsy

Sudden Unexpected Death in Epilepsy (SUDEP)

Date/Time: Monday, October 24, 2022 - 3:45 PM – 5:45 PM
Track: Traditional Special Interest Group
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Description:

Sudden Unexpected Death in Epilepsy (SUDEP), the non-traumatic and non-drowning death of a person with epilepsy in which post-mortem examination does not reveal a toxicologic or anatomic cause, is the leading cause of death for persons with uncontrolled epilepsy. The incidence of SUDEP ranges from 0.09 per 1000 patient-years to 0.9 per 1000 patient-years, depending on epilepsy severity and patient population studied. While awareness about SUDEP has grown in recent years, still much is unknown about SUDEP or how to prevent it. Proposed mechanisms of SUDEP include cardiac arrhythmia and respiratory depression.  Additionally, several clinical risk factors have been identified, including frequent generalized tonic-clonic seizures. In this session, we will review the contemporary understanding of SUDEP pathophysiology and clinical risk factors, identify challenges and future directions of SUDEP research, and explore current applications to the clinical care of patients with epilepsy.

Chair: Chloe E. Hill, MD, MS

Co-Chair: Colin A. Ellis, MD

Objectives:

  • Demonstrate an understanding of SUDEP pathophysiology and clinical risk factors
  • Identify challenges and future directions of SUDEP research
  • Apply contemporary SUDEP research to the clinical care of patients with epilepsy 

Exploring SUDEP Cardiac Mechanisms with Human Cellular and Novel Animal Models

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Sleep-Wake and Respiratory Mechanisms of SUDEP

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Sudden Unexpected Death in Epilepsy

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SUDEP and Brainstem Mechanisms

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VIP Interneuron Dysfunction Underlies Impaired Neocortical State Transitions and Behavior in a Model of Dravet Syndrome

Poster Presenter: Ethan Goldberg, MD, PhD, University of Pennsylvania


 

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